Systems Biology of Drug Resistance Evolution

How to get here:
Cuernavaca, Mexico

The euphemistic term "emergence" is often used in medicine to describe the evolutionary processes by which living systems acquire resistance to chemotherapy. The purpose of this meeting is to understand clinical resistance from the perspective that it is best understood, and therefore controlled, if we adopt an evolutionary perspective from the start.

Reflecting the importance of the different disciplines needed to tackle the problem of drug resistance, our invited speakers represent a wide range of methodological approaches.

With an emphasis on the relevance to past but also potential future clinical studies, speakers will address different aspects of the resistance problem. Topics for discussion include antibiotic discovery, antibiotic stewardship in the clinic, rapid pathogen diagnosis, bioinformatics approaches to clinical resistance adaptation, reduced-dose trials using malaria in vivo models, in vitro models of resistance adaptation studied using ideas from systems biology, in addition to theoretical, epidemiological modelling.

Previous meetings

  • Microbial Communities: From the Lab to Natural Environments
    Devon, UK, 17-19 April 2013

    The aim of this workshop is to bridge the gap between mathematical models, laboratory models and natural ecosystems. Speakers talked about plant and human pathogens, natural fungal ecosystems, consortia of symbionts, their responses to antibiotics and viruses and single-cell observations of bacteria in microfluidic devices.

  • Mathematics of Microbes: Biological Details of the Evolving Cell
    London, 27-29 April 2011

    An international conference assembling a cross-disciplinary panel of internationally leading speakers presenting current research relating to microbes and antimicrobials, including the action of, and evolution of resistance to antibiotics, phage and peptides. A central theme is 'detail and ecology': how far inside the cell must we look to understand what is happening outside?

  • Evolution of Microbial Cooperation
    University of Bath, 20-21 January 2011

    The workshop will bring together experimentalists and modelers interested in microbial cooperation from molecular and genetic detail thought to population level interactions.

  • Coevolution: Models and microbial model systems
    University of Liverpool, 14-15 April 2010

    Coevolution is a fundamental process in evolution. The aim of this workshop is to bring together empiricists using experimental evolution to study coevolution with theoreticians to develop new modelling approaches and to highlight exciting new developments of coevolutionary theory requiring experimental tests.


  • Evolution of Stress Responses
    University of Aberdeen, 18-19 September 2009

    The workshop broadly covered eukaryotic and prokaryotic stress responses at both cell and population levels.

  • Evolution of Antibiotic Resistance
    Imperial College London, 14th and 15th of January 2009

    The aim of the workshop is to bring together the following three groups of scientists: experts in genotyping, experimental evolution and mathematical modeling.

  • Mathematical Models and Experimental Microbial Systems: Tools for Studying Evolution
    University of Bath, 5-7 June 2007

    This workshop is intended to provide an arena for much-needed interaction between microbial experimentalists and mathematicians focused around the following evolutionary questions: What determines species diversity? and How did cooperative behaviour evolve?